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Our finding that bacterial RNAs can localize to different cellular domains independently of translation (Science, 2011) challenged the dogma that transcription and translation are always coupled. Analysis of the E. coli transcriptome revealed that a significant fraction localizes asymmetrically, often correlating with proteome distribution and independent of translation (Mol. Cell, 2019). Notably, the polar transcriptome is unique, enriched in specific mRNAs and most small RNAs (sRNAs). […]
CRISPR-Cas systems are adaptive immune systems found in bacteria or archaea that protect against the invading of mobile genetic elements (MGEs), such as phages and plasmids. To defend against foreign nucleic acids, CRISPR-Cas systems capture short DNA segments from invaders and insert them into the CRISPR array, thus recording a genetic snapshot of potential threats. The CRISPR locus is then transcribed and processed to generate CRISPR RNA (crRNA) that binds and guides the Cas protein effector complex to cleave the genome of the invader when it returns. To counteract CRISPR-Cas systems, […]
Jewel-like memories
Structure and mechanism of a methyl transferase ribozyme
Computational modeling of RNA 3D structures and interactions with the use of experimental data
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Prof. Orna Amster-Choder, Full Professor, Faculty of Medicine, Department of Microbiology and Molecular Genetics – The Hebrew University, Jerusalem, Israel, will give a talk on Revisiting the dogma on bacterial transcriptome organization: implications on gene expression.
Our finding that bacterial RNAs can localize to different cellular domains independently of translation (Science, 2011) challenged the dogma that transcription and translation are always coupled. Analysis of the E. coli transcriptome revealed that a significant fraction localizes asymmetrically, often correlating with proteome distribution and independent of translation (Mol. Cell, 2019). Notably, the polar transcriptome is unique, enriched in specific mRNAs and most small RNAs (sRNAs).
sRNA: We demonstrated a polygenic plan for sRNA-mediated regulation, explaining the subtle effects of specific sRNA deletions (iScience, 2021). We also found that sRNAs are accompanied by their chaperone Hfq, which undergoes phase separation at the poles, a process essential for its activity (Cell Rep, 2022). Multiomic analyses suggest compartmentalization of certain metabolic pathways, including ATP production, in these regions.
mRNA: We recently showed that the pole-to-pole oscillating MinD protein and RNase E control mRNA enrichment at the poles by preventing site-specific degradation. Mislocalization of polar mRNAs may disrupt protein localization, indicating localized translation in bacteria (EMBO J, 2024).
Coupled transcription-translation (CTT): We developed a method to map the transcriptome-wide CTT landscape in three model organisms at near-single codon resolution. Our results indicate that significant gene expression occurs without CTT and identify factors influencing CTT dynamics.
For more information about her outstanding work, please visit her profile at
https://amsterchoder.huji.ac.il/
Time (China): 2025-3-27 16:00
Zoom meeting: 893 0005 4861
Passcode: 123456
Zoom meeting link:
https://us06web.zoom.us/j/89300054861?pwd=TZbjJuSwrz4lTdg8yKCwDKKDDzqwNe.1
bilibili live link:
https://live.bilibili.com/26427894
Welcome to follow the Guangzhou RNA club official account GzRNA, we will see you on Mar. 27th 2025!
Thanks to the International RNA Society, 表观生物, 博奥龙, 新使生物 and LEXOGEN for their sponsorship support!
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Based on the applications of the pre-conference participants, 13 students have been awarded 2023 RNA Society trainee memberships for free. It is great to see the participation of students from different institutions, such as Lanzhou University, Nankai University, SIBS, Shanghai Jiaotong University, Melbourne University, Guangzhou Medical University, ShenZhen Bay Laboratory, Sun Yat-sen University and so on.
根据前期会议参与同学申请情况，13位同学已免费获得 2023 RNA Society trainee memberships。很高兴看到不同单位的同学申请，兰大，南开，SIBS，上交，墨尔本，广医，深圳湾，双鸭山等等。
We are organising RNA-Puzzles, which is a community-wide blind assessment of RNA 3D structure prediction. We also work on AI-based RNA design and RNA virus related research.
My lab is interested in the structure and function of nucleic acid aptamers, riboswitches, protein-nucleic acid interactions and catalytic activity in nucleic acids.
My research interests focus on the development and application of experimental and computational methods to discover novel classes of ncRNAs and their functions and mechanisms.
We are interested in eluciding the mechanisms and regulatory roles of RNA modifications on different classes of RNAs through close integration of bioinformatic method development with biochemical experiments.
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96 Xingdao South Road, Guangzhou International Bio Island,
Haizhu District, Guangzhou, Guangdong, China. (Maps)
Guangzhou RNA club