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Extensive epigenetic programming and reprogramming take place in the mammalian early embryos after fertilization to start the life program of new individuals, at both the chromatin level and the RNA level. At the chromatin level, we reveal the dynamics and regulation of chromatin accessibility during early embryonic development and identify a new type of non-canonically imprinted genes in the pre-implantation embryo that are regulated by tri-methylation at the lysine 27 of histone H3 (H3K27me3). We reveal that the non-canonical imprinting plays an important role in post-implantation embryonic development. […]
Adenosine-to-Inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is prevalent in metazoans. Previous research, including our own, has revealed that the primary function of RNA editing by ADAR1 is to ensure sufficient editing of cellular double-stranded RNA (dsRNA), thereby preventing erroneous cytosolic MDA5-mediated dsRNA sensing. Mice lacking RNA editing by ADAR1 experience embryonic lethality but can live their full lifespan upon removal of MDA5. In humans, loss-of-function mutations in ADAR1 and gain-of-function mutations in MDA5 result in rare autoimmune diseases. Our recent work, through human genetics studies, reveals that RNA editing plays a central role in common autoimmune and immune-related diseases. This well-established ADAR1-dsRNA-MDA5 axis serves as the foundation for therapeutic development in the treatment of cancer and autoinflammatory diseases. […]
Jewel-like memories
Structure and mechanism of a methyl transferase ribozyme
Computational modeling of RNA 3D structures and interactions with the use of experimental data
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Dr. Falong Lu, Institute of Genetics and Developmental Biology, CAS, will give a talk on Epigenetic Programming and Reprogramming in Mammals at the Beginning of Life.
Extensive epigenetic programming and reprogramming take place in the mammalian early embryos after fertilization to start the life program of new individuals, at both the chromatin level and the RNA level. At the chromatin level, we reveal the dynamics and regulation of chromatin accessibility during early embryonic development and identify a new type of non-canonically imprinted genes in the pre-implantation embryo that are regulated by tri-methylation at the lysine 27 of histone H3 (H3K27me3). We reveal that the non-canonical imprinting plays an important role in post-implantation embryonic development. At the RNA level, we reveal the presence of widespread non-A residues within the body of RNA poly(A) tails which may encode a new layer of RNA epigenetic regulatory information. We reveal mRNA poly(A) tail-mediated maternal mRNA remodeling in the human early embryos, and its critical role for the first cell division of the human embryos. These findings not only reveal novel epigenetic regulatory mechanisms, but also shed lights on our understanding of the regulatory mechanisms underlying the start of a mammalian individual.
For more information about her outstanding work, please visit her profile at
https://genetics.cas.cn/edu/dsdw_187548/fyswxyjzx_187551/202201/t20220113_6340946.html
Time(China): 2024-09-27 09:30 AM
Tencent Meeting：959-378-696
Address: Room 102, Lecture Hall, Building 2, School of Life Sciences, Sun Yat-sen University
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Based on the applications of the pre-conference participants, 13 students have been awarded 2023 RNA Society trainee memberships for free. It is great to see the participation of students from different institutions, such as Lanzhou University, Nankai University, SIBS, Shanghai Jiaotong University, Melbourne University, Guangzhou Medical University, ShenZhen Bay Laboratory, Sun Yat-sen University and so on.
根据前期会议参与同学申请情况，13位同学已免费获得 2023 RNA Society trainee memberships。很高兴看到不同单位的同学申请，兰大，南开，SIBS，上交，墨尔本，广医，深圳湾，双鸭山等等。
We are organising RNA-Puzzles, which is a community-wide blind assessment of RNA 3D structure prediction. We also work on AI-based RNA design and RNA virus related research.
My lab is interested in the structure and function of nucleic acid aptamers, riboswitches, protein-nucleic acid interactions and catalytic activity in nucleic acids.
My research interests focus on the development and application of experimental and computational methods to discover novel classes of ncRNAs and their functions and mechanisms.
We are interested in eluciding the mechanisms and regulatory roles of RNA modifications on different classes of RNAs through close integration of bioinformatic method development with biochemical experiments.
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Guangzhou RNA club