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Redmond Smyth carried out his undergraduate degree in Natural Sciences at the University of Cambridge (UK), specializing in Virology and Immunology. He then moved to the Burnet Institute, Melbourne (Australia) for his PhD, where he investigated the mechanisms of HIV-1 genetic diversity in its natural target cells. His PhD research pointed to the importance of RNA structure in regulating viral infection processes, which is why he then moved to Strasbourg (France) for his post-doctoral research to train as an RNA biochemist. he worked on understanding the mechanisms leading to the incorporation of the HIV-1 genomic RNA into viral particles. In 2015, he was recruited to the CNRS as a chargé de recherché (CR2), and in 2018, with support from the Helmholtz Association, he started his own research group at the Helmholtz Institute for RNA-based Infection Research (HIRI). […]
Franck Martin is a Research Director from CNRS at the University of Strasbourg, France. He is principal investigator at the ‘Institut de Biologie Moléculaire et Cellulaire’ in the department ‘Architecture et Réactivité de l’ARN’ (RNA architecture and reactivity). In eukaryotes, translation initiation is a highly regulated process involving cis-regulatory sequences on messenger RNA and eukaryotic initiation factors (eIF). Canonical translation is cap-dependent, leading to the assembly of an elongation-competent ribosome at the start codon. However, alternative cap-independent translation initiation mechanisms are activated in response to stimuli such as viral infections and cellular stresses. […]
Jewel-like memories
Structure and mechanism of a methyl transferase ribozyme
Computational modeling of RNA 3D structures and interactions with the use of experimental data
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Dr. Franck MARTIN, Research Director from CNRS at the University of Strasbourg, France, will give a talk on Translation initiation in eukaryotes: from viruses to human pathological cases.
In eukaryotes, translation initiation is a highly regulated process involving cis-regulatory sequences on messenger RNA and eukaryotic initiation factors (eIF). Canonical translation is cap-dependent, leading to the assembly of an elongation-competent ribosome at the start codon. However, alternative cap-independent translation initiation mechanisms are activated in response to stimuli such as viral infections and cellular stresses.We studied translation mechanisms during SARS-CoV-2 infection. The viral protein NSP1 binds to host ribosomes, inhibiting cellular translation to favor viral translation, while also acting as an RNA endonuclease that cleaves host mRNAs. Dysregulation of translation initiation can lead to human pathologies. For instance, in Amyotrophic Lateral Sclerosis, Repeat-Associated Non AUG (RAN) translation produces toxic polypeptides that damage motor neurons. In Alzheimer’s disease, alternative translation initiation of Tau mRNAs results in a truncated, aggregation-prone form of the Tau protein.
For more information about her outstanding work, please visit her profile at
https://sciprofiles.com/profile/711119
Time (China): 2024-11-5 09:00 AM
Time (EST): 2024-11-4 08:00 PM
Zoom ID: 811 0745 9920
Passcode: 123456
Zoom meeting link: https://us06web.zoom.us/j/81107459920?pwd=FywefBaBGMOfR3vdauiXHWF7sTU9ua.1
bilibili live link:
https://live.bilibili.com/26427894
Welcome to follow the Guangzhou RNA club official account GzRNA, we will see you on Oct 18th 2024!
Thanks to the International RNA Society, 博奥龙, 表观生物, 擎科生物, 厚泽生物 and LEXOGEN for their sponsorship support!
Dr. Redmond Smyth, Helmholtz Institute for RNA-based Infection Research (HIRI), France, will give a talk on Probing the role of RNA structural heterogeneity in viral RNAs.
RNA is a dynamic molecule capable of adopting multiple structures that can interconvert to fulfill its functional roles. The emerging understanding of RNA structural heterogeneity highlights the significance of these conformational changes in regulating processes within viral life cycles. Traditional in-solution chemical probing has been invaluable in studying RNA structure within cells but is limited by its ensemble nature, which averages structural information across all conformations. To overcome this limitation, we developed and applied two complementary strategies. FARS-seq combines physical separation of RNA conformations with high-throughput functional profiling, revealing key motifs in the HIV-1 5′ untranslated region (UTR) that impact dimerization and Pr55Gag binding. Meanwhile, Nano-DMS-MaP leverages long-read sequencing to provide isoform-resolved structural insights, identifying distinct structural differences between unspliced and spliced HIV-1 RNAs at the packaging site. These differences likely account for the selective packaging of unspliced RNAs into viral particles. Together, FARS-seq and Nano-DMS-MaP offer new approaches to elucidate the role of RNA structural heterogeneity in viral genome regulation.
For more information about her outstanding work, please visit her profile at
https://www.helmholtz-hzi.de/en/persons/dr-redmond-smyth/
Time (China): 2024-11-06 20:00
Time (EST): 2024-11-06 13:00
Zoom ID: 833 7115 9253
Passcode: 123456
Zoom meeting link: https://us06web.zoom.us/j/83371159253?pwd=vKbGPpYr7OmbKhIPhLDzTmSWqwrCUm.1
bilibili live link:
https://live.bilibili.com/26427894
Welcome to follow the Guangzhou RNA club official account GzRNA, we will see you on Oct 18th 2024!
Thanks to the International RNA Society, 博奥龙, 表观生物, 擎科生物, 厚泽生物 and LEXOGEN for their sponsorship support!
More people are welcome!
Based on the applications of the pre-conference participants, 13 students have been awarded 2023 RNA Society trainee memberships for free. It is great to see the participation of students from different institutions, such as Lanzhou University, Nankai University, SIBS, Shanghai Jiaotong University, Melbourne University, Guangzhou Medical University, ShenZhen Bay Laboratory, Sun Yat-sen University and so on.
根据前期会议参与同学申请情况，13位同学已免费获得 2023 RNA Society trainee memberships。很高兴看到不同单位的同学申请，兰大，南开，SIBS，上交，墨尔本，广医，深圳湾，双鸭山等等。
We are organising RNA-Puzzles, which is a community-wide blind assessment of RNA 3D structure prediction. We also work on AI-based RNA design and RNA virus related research.
My lab is interested in the structure and function of nucleic acid aptamers, riboswitches, protein-nucleic acid interactions and catalytic activity in nucleic acids.
My research interests focus on the development and application of experimental and computational methods to discover novel classes of ncRNAs and their functions and mechanisms.
We are interested in eluciding the mechanisms and regulatory roles of RNA modifications on different classes of RNAs through close integration of bioinformatic method development with biochemical experiments.
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We are part of the Guangzhou International Bioland.
Contact:
Building B2, Guangzhou Laboratory
96 Xingdao South Road, Guangzhou International Bio Island,
Haizhu District, Guangzhou, Guangdong, China. (Maps)
Guangzhou RNA club